Transdermal delivery of ketorolac tromethamine: permeation enhancement, device design, and pharmacokinetics in healthy humans.

@article{Roy1995TransdermalDO,
  title={Transdermal delivery of ketorolac tromethamine: permeation enhancement, device design, and pharmacokinetics in healthy humans.},
  author={Sudipta Dutta Roy and Elizabeth Manoukian},
  journal={Journal of pharmaceutical sciences},
  year={1995},
  volume={84 10},
  pages={1190-6}
}
Transdermal delivery of ketorolac tromethamine, a potent non-narcotic analgesic, through human skin in vitro and in vivo was investigated. In order to enhance and sustain the flux of ketorolac through human skin, various compositions of isopropyl alcohol (IPA), water, and isopropyl myristate (IPM) were evaluated. The solubility of ketorolac acid in an IPA… CONTINUE READING