Transdermal delivery of indomethacin by iontophoresis.

@article{Kanebako2002TransdermalDO,
  title={Transdermal delivery of indomethacin by iontophoresis.},
  author={Makoto Kanebako and Toshio Inagi and Kozo Takayama},
  journal={Biological & pharmaceutical bulletin},
  year={2002},
  volume={25 6},
  pages={
          779-82
        }
}
The objective of this study was to construct a modified equation for the delivery of a drug by iontophoresis. Indomethacin was selected as a model since it has been widely used as a non-steroidal anti-inflammatory drug (NSAID) for external pharmaceutical preparations. The experiments were performed under a constant current in vivo using rat abdominal skin, and the plasma concentration was monitored by HPLC. Pharmacokinetic parameters were obtained from the plasma concentration profiles after… CONTINUE READING
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