Transdermal delivery of imipramine and doxepin from newly oil-in-water nanoemulsions for an analgesic and anti-allodynic activity: development, characterization and in vivo evaluation.

Abstract

Antidepressants have been considered by their analgesic activity in numerous studies, and specifically tricyclic antidepressants to possess the greatest efficacy. Imipramine and doxepin have been reported to exhibit local anaesthetic properties. In order to investigate their cutaneous analgesic effect after topical application a nanoemulsion vehicle was… (More)
DOI: 10.1016/j.colsurfb.2012.10.061

Cite this paper

@article{Sandig2013TransdermalDO, title={Transdermal delivery of imipramine and doxepin from newly oil-in-water nanoemulsions for an analgesic and anti-allodynic activity: development, characterization and in vivo evaluation.}, author={A Gimeno Sandig and A C Calpena Campmany and Frederico F. Campos and Mar{\'i}a Jos{\'e} Mart{\'i}n Villena and B Clares Naveros}, journal={Colloids and surfaces. B, Biointerfaces}, year={2013}, volume={103}, pages={558-65} }