Transdermal delivery of (-)-epigallocatechin-3-gallate, a green tea polyphenol, in mice.

  title={Transdermal delivery of (-)-epigallocatechin-3-gallate, a green tea polyphenol, in mice.},
  author={Joshua D Lambert and Dou Hwan Kim and Ruijin Zheng and Chung S Yang},
  journal={The Journal of pharmacy and pharmacology},
  volume={58 5},
Epigallocatechin-3-gallate (EGCG) is the most studied catechin in green tea (Camellia sinensis). EGCG and green tea are cancer preventive in many animal models, and numerous mechanisms have been proposed in cell lines. EGCG is poorly bioavailable in man and rodents. We hypothesized that transdermal delivery of EGCG could result in improved bioavailability. Following application of EGCG transdermal gel (50 mg kg(-1), t.d.) to SKH-1 mice, EGCG was observed in the epidermis (1365.7-121.0 ng g(-1… CONTINUE READING


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