Transdermal cannabidiol reduces inflammation and pain‐related behaviours in a rat model of arthritis

  title={Transdermal cannabidiol reduces inflammation and pain‐related behaviours in a rat model of arthritis},
  author={D. C. Hammell and L. Zhang and F. Ma and S. Abshire and S. L. McIlwrath and A. Stinchcomb and K. Westlund},
  journal={European Journal of Pain},
  • D. C. Hammell, L. Zhang, +4 authors K. Westlund
  • Published 2016
  • Medicine
  • European Journal of Pain
  • BACKGROUND Current arthritis treatments often have side-effects attributable to active compounds as well as route of administration. [...] Key Method CBD gels (0.6, 3.1, 6.2 or 62.3 mg/day) were applied for 4 consecutive days after arthritis induction. Joint circumference and immune cell invasion in histological sections were measured to indicate level of inflammation. Paw withdrawal latency (PWL) in response to noxious heat stimulation determined nociceptive sensitization, and exploratory behaviour ascertained…Expand Abstract

    Paper Mentions

    This randomized, double-blind 2-arm parallel group study to determine the efficacy of a cannabinoid (CBD) patch on reducing pain in patients with knee osteoarthritis.  
    ConditionsCBD, Knee Osteoarthritis, Osteoarthritis
    InterventionDrug, Other
    Cannabinoid Delivery Systems for Pain and Inflammation Treatment
    • 35
    • PDF
    Could cannabidiol play a role in the treatment of chronic pain
    Attenuation of early phase inflammation by cannabidiol prevents pain and nerve damage in rat osteoarthritis
    • 42
    • Highly Influenced
    • PDF
    Chronic pain and cannabinoids. Great expectations or a christmas carol
    • 5


    Publications referenced by this paper.
    Cannabidiol: An Overview of Some Pharmacological Aspects
    • 314
    • PDF
    The nonpsychoactive cannabis constituent cannabidiol is an oral anti-arthritic therapeutic in murine collagen-induced arthritis.
    • 441
    • Highly Influential
    • PDF
    Cannabinoids, Endocannabinoids, and Related Analogs in Inflammation
    • 91
    • PDF
    Cannabidiol: an overview of some chemical and pharmacological aspects. Part I: chemical aspects.
    • 135
    • PDF