Transdermal cannabidiol reduces inflammation and pain‐related behaviours in a rat model of arthritis

  title={Transdermal cannabidiol reduces inflammation and pain‐related behaviours in a rat model of arthritis},
  author={D. C. Hammell and L. Zhang and F. Ma and S. Abshire and S. L. McIlwrath and A. Stinchcomb and K. Westlund},
  journal={European Journal of Pain},
  • D. C. Hammell, L. Zhang, +4 authors K. Westlund
  • Published 2016
  • Medicine
  • European Journal of Pain
  • BACKGROUND Current arthritis treatments often have side-effects attributable to active compounds as well as route of administration. [...] Key Method CBD gels (0.6, 3.1, 6.2 or 62.3 mg/day) were applied for 4 consecutive days after arthritis induction. Joint circumference and immune cell invasion in histological sections were measured to indicate level of inflammation. Paw withdrawal latency (PWL) in response to noxious heat stimulation determined nociceptive sensitization, and exploratory behaviour ascertained…Expand Abstract
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