Transdermal cannabidiol reduces inflammation and pain-related behaviours in a rat model of arthritis.

@article{Hammell2016TransdermalCR,
  title={Transdermal cannabidiol reduces inflammation and pain-related behaviours in a rat model of arthritis.},
  author={Dana C. Hammell and L P Zhang and Fei Ma and Sarah M Abshire and Sabrina L. McIlwrath and Audra L Stinchcomb and Karin N. Westlund},
  journal={European journal of pain},
  year={2016},
  volume={20 6},
  pages={936-48}
}
BACKGROUND Current arthritis treatments often have side-effects attributable to active compounds as well as route of administration. Cannabidiol (CBD) attenuates inflammation and pain without side-effects, but CBD is hydrophobic and has poor oral bioavailability. Topical drug application avoids gastrointestinal administration, first pass metabolism, providing more constant plasma levels. METHODS This study examined efficacy of transdermal CBD for reduction in inflammation and pain, assessing… CONTINUE READING

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