Transdermal bioavailability and first-pass skin metabolism: A preliminary evaluation with nitroglycerin

  title={Transdermal bioavailability and first-pass skin metabolism: A preliminary evaluation with nitroglycerin},
  author={Emi Nakashima and Patrick K. Noonan and Leslie Z Benet},
  journal={Journal of Pharmacokinetics and Biopharmaceutics},
A model comprising six compartments, a systemic and presystemic compartment for nitroglycerin and each of its two dinitrate metabolites is presented to describe the interrelationships between plasma concentrations of the two metabolites and metabolism in skin after intravenous and transdermal ointment administration of nitroglycerin. Using a perfusion-limited pharmacokinetic model, the equation for the calculation of the fraction (F)of the dose of nitroglycerin systemically available from skin… CONTINUE READING

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