Transdermal absorption and topical bioavailability of coumarin.


Coumarin was administered I.V., P.O. and topically to male Sprague-Dawley rats. The concentration-time profile after I.V. administration could be best described by an open-two compartment model. After P.O. administration the fraction of drug absorbed was 0.21 +/- 0.08 (S.D.). 1 g of hydrophilic ointment (U.S.P. XIX) containing 5% w/w of coumarin was applied… (More)


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@article{Ritschel1988TransdermalAA, title={Transdermal absorption and topical bioavailability of coumarin.}, author={W. Ritschel and S. A. Hussain}, journal={Methods and findings in experimental and clinical pharmacology}, year={1988}, volume={10 3}, pages={165-9} }