Transdermal Scopolamine: An Alternative to Ondansetron and Droperidol for the Prevention of Postoperative and Postdischarge Emetic Symptoms
@article{White2007TransdermalSA, title={Transdermal Scopolamine: An Alternative to Ondansetron and Droperidol for the Prevention of Postoperative and Postdischarge Emetic Symptoms}, author={Paul F. White and Jun Tang and Dajun Song and Jayne E. Coleman and Ronald H. Wender and Babatunde O. Ogunnaike and Alexander Sloninsky and Rajani Kapu and Mary Shah and Thomas Webb}, journal={Anesthesia \& Analgesia}, year={2007}, volume={104}, pages={92-96} }
BACKGROUND:Given the controversy regarding the use of droperidol and the high cost of the 5-HT3 antagonists, a cost-effective alternative for routine use as a prophylactic antiemetic would be desirable. We designed two parallel, randomized, double-blind sham and placebo-controlled studies to compare the early and late antiemetic efficacy and adverse event profile of transdermal scopolamine (TDS) 1.5 mg, to ondansetron 4 mg IV, and droperidol 1.25 mg IV for antiemetic prophylaxis as part of a…
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