Transdermal Scopolamine: An Alternative to Ondansetron and Droperidol for the Prevention of Postoperative and Postdischarge Emetic Symptoms

  title={Transdermal Scopolamine: An Alternative to Ondansetron and Droperidol for the Prevention of Postoperative and Postdischarge Emetic Symptoms},
  author={P. White and J. Tang and D. Song and J. Coleman and R. Wender and B. Ogunnaike and A. Sloninsky and Rajani Kapu and M. Shah and T. Webb},
  journal={Anesthesia & Analgesia},
  • P. White, J. Tang, +7 authors T. Webb
  • Published 2007
  • Medicine
  • Anesthesia & Analgesia
  • BACKGROUND:Given the controversy regarding the use of droperidol and the high cost of the 5-HT3 antagonists, a cost-effective alternative for routine use as a prophylactic antiemetic would be desirable. We designed two parallel, randomized, double-blind sham and placebo-controlled studies to compare the early and late antiemetic efficacy and adverse event profile of transdermal scopolamine (TDS) 1.5 mg, to ondansetron 4 mg IV, and droperidol 1.25 mg IV for antiemetic prophylaxis as part of a… CONTINUE READING
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