Transdermal Oxybutynin

@article{Baldwin2012TransdermalO,
  title={Transdermal Oxybutynin},
  author={Claudine M. Baldwin and Gillian M. Keating},
  journal={Drugs},
  year={2012},
  volume={69},
  pages={327-337}
}
Abstract▴ Oxybutynin inhibits contraction of the detrusor muscle in the overactive bladder by binding to muscarinic M3 receptors and blocking acetylcholinergic activation.▴ The transdermal oxybutynin system, applied twice weekly, delivers continuous oxybutynin over a 96-hour patch wear period. The transdermal route of administration avoids the extensive first-pass metabolism of oxybutynin to its active metabolite, N- desethyloxybutynin.▴ In two well designed trials in patients with overactive… Expand
The value of oxybutynin in transdermal patches for treating overactive bladder.
TLDR
OXY-TDS represents an effective alternative for the symptomatic treatment of adult patients with OAB, which, thanks to its pharmacokinetic profile, better tolerability, different administration method and dosage, could represent an added value in treating special populations. Expand
Insights into the Management of Overactive Bladder with Transdermal Oxybutynin: A Practical Review
TLDR
Evidence available of the use of OXY-TDS in the management of patients with OAB is focused on to help clinicians in the challenges involved in the treatment options for patients with this condition. Expand
Botulinum Toxin A’s Expanding Role in the Management of Pediatric Lower Urinary Tract Dysfunction
TLDR
Botulinum toxin A’s utility in the pediatric population is evolving, and is currently being used in the treatment of lower urinary tract dysfunction, both in children with neuropathic compromise, and non-neuropathic overactive bladders. Expand
Management of Mixed Urinary Incontinence
TLDR
Treatment includes lifestyle changes, behavioral therapies, medication and nerve modulation, and future therapies may include new medications adapting potassium and calcium channels and more widespread use of sacral neuromodulation. Expand
Management of urinary incontinence.
TLDR
The authors report that they have no financial, commercial, or industrial relationships in regard to this article. Expand
Bladder Outlet Obstruction and Overactive Bladder in Males

References

SHOWING 1-10 OF 30 REFERENCES
Oxybutynin. A review of its pharmacodynamic and pharmacokinetic properties, and its therapeutic use in detrusor instability.
TLDR
Despite the occurrence of unwanted anticholinergic effects in many patients, and apparent lack of efficacy in the elderly institutionalised population, oxybutynin should be considered for the drug of first choice in patients with detrusor overactivity, including the elderly ambulatory population, when pharmacological therapy is indicated. Expand
Management of overactive bladder with transdermal oxybutynin.
TLDR
Transdermal oxybutynin (OXY-TDS) has shown comparable efficacy and improved tolerability when compared with conventional pharmacotherapy, and has unique dermatologic skin application site reactions, including erythema and pruritus. Expand
Advantages for Transdermal over Oral Oxybutynin to Treat Overactive Bladder: Muscarinic Receptor Binding, Plasma Drug Concentration, and Salivary Secretion
TLDR
The present study has shown that transdermal oxy butynin binds significantly to rat bladder muscarinic receptors without producing both long-lasting occupation of exocrine receptors and cessation of cholinergic salivation evoked by oral oxybutynin. Expand
Transdermal oxybutynin in the treatment of adults with overactive bladder: combined results of two randomized clinical trials
TLDR
Transdermal oxybutynin was shown to be efficacious, with a proven safety profile, and may be utilized for patients with overactive bladder as a treatment option that could enhance compliance. Expand
Transdermal oxybutynin for overactive bladder.
TLDR
This novel oxybutynin formulation offers patients who have over active bladder and urge urinary incontinence a well-tolerated option for managing the symptoms of overactive bladder. Expand
Comparison of oxybutynin and its active metabolite, N-desethyl-oxybutynin, in the human detrusor and parotid gland.
TLDR
It is concluded that oxybutynin and N-desethyl-oxy butynin have a similar antimuscarinic effect in the human detrusor, and the same binding characteristics indetrusor and parotid gland, respectively. Expand
Efficacy and safety of transdermal oxybutynin in patients with urge and mixed urinary incontinence.
PURPOSE We evaluated the efficacy and safety of an oxybutynin transdermal delivery system (TDS) in a general population of patients with overactive bladder and urge or mixed urinary incontinence. Expand
Comparative efficacy and safety of transdermal oxybutynin and oral tolterodine versus placebo in previously treated patients with urge and mixed urinary incontinence.
TLDR
OXY-TDS improves systemic safety with regard to anticholinergic side effects and TOL-LA are effective and comparable treatments for patients with urge and mixed incontinence. Expand
Impact of Transdermal Oxybutynin on Work Productivity in Patients with Overactive Bladder
TLDR
OAB contributes to decreased work productivity due to job interruptions as well as fatigue and may result in productivity improvement when patients receive 3.9 mg/day via twice weekly patch application for up to 6 months with OXY-TDS treatment. Expand
Pharmacokinetics of the R- and S-Enantiomers of Oxybutynin and N-Desethyloxybutynin Following Oral and Transdermal Administration of the Racemate in Healthy Volunteers
TLDR
The differences between R-OXY and R-DEO following the two routes of administration support the potential for comparable clinical efficacy and reduced anticholinergic side-effects with transdermal treatment. Expand
...
1
2
3
...