Transdermal Oxybutynin

@article{Baldwin2012TransdermalO,
  title={Transdermal Oxybutynin},
  author={Claudine M. Baldwin and Gillian M. Keating},
  journal={Drugs},
  year={2012},
  volume={69},
  pages={327-337}
}
Abstract▴ Oxybutynin inhibits contraction of the detrusor muscle in the overactive bladder by binding to muscarinic M3 receptors and blocking acetylcholinergic activation.▴ The transdermal oxybutynin system, applied twice weekly, delivers continuous oxybutynin over a 96-hour patch wear period. The transdermal route of administration avoids the extensive first-pass metabolism of oxybutynin to its active metabolite, N- desethyloxybutynin.▴ In two well designed trials in patients with overactive… 

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TLDR
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TLDR
The differences between R-OXY and R-DEO following the two routes of administration support the potential for comparable clinical efficacy and reduced anticholinergic side-effects with transdermal treatment.