Transdermal Nicotine for Mildly to Moderately Active Ulcerative Colitis

@article{Sandborn1997TransdermalNF,
  title={Transdermal Nicotine for Mildly to Moderately Active Ulcerative Colitis},
  author={W. Sandborn and W. Tremaine and K. Offord and G. Lawson and Brett Petersen and K. Batts and I. Croghan and L. Dale and D. Schroeder and R. Hurt},
  journal={Annals of Internal Medicine},
  year={1997},
  volume={126},
  pages={364-371}
}
Ulcerative colitis is primarily a disease of nonsmokers [1-4]. Nonsmokers who have ulcerative colitis and begin smoking may go into remission [5]. These observations led to uncontrolled trials of nicotine administered through chewing gum [6] or a transdermal patch [7]. A controlled trial of 15 to 25 mg of transdermal nicotine for active ulcerative colitis reported that 49% of patients responded to nicotine, whereas only 24% responded to placebo [8]. A subsequent controlled trial of 15 mg of… Expand
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The results of this review provide evidence that transdermal nicotine is superior to placebo for the induction of remission in ulcerative colitis, and a meta-analysis of five trials showed a statistically significant benefit for nicotine treatment. Expand
The Efficacy Of Transdermal Nicotine In Conjunction With Conventional Therapies In Active Ulcerative Colitis
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The hypothesis states that using nicotine as an adjunct to standard medical therapy (i.e. azulfidine and steroids) in active disease would be more efficacious than standard therapy alone in inducing remission in 6 weeks. Expand
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  • Medicine
  • British journal of clinical pharmacology
  • 1999
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The introduction of transdermal nicotine in the market made it possible to assess the potential therapeutic role of nicotine in a more extensive way and yielded encouraging but inconclusive results. Expand
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Six-milligram nicotine enemas were well tolerated but were not found to be efficacious for active UC. Expand
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Oral nicotine is a safe potential treatment of inflammatory bowel disease, but there is considerable variation in tolerance, and the effect on disease activity was also noted. Expand
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TLDR
The addition of transdermal nicotine to conventional maintenance therapy improves symptoms in patients with ulcerative colitis. Expand
Transdermal nicotine as maintenance therapy for ulcerative colitis.
TLDR
Transdermal nicotine alone was no better than placebo in the maintenance of remission of ulcerative colitis, and premature withdrawal due to side effects was more common in the nicotine group. Expand
Transdermal nicotine compared with oral prednisolone therapy for active ulcerative colitis.
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In patients with active ulcerative colitis, nicotine alone appeared to be of only very modest benefit in acute colitis and was not as effective as 15 mg of prednisolone daily. Expand
Testing nicotine gum for ulcerative colitis patients. Experience with single-patient trials.
TLDR
It is concluded that a randomized trial for an individual patient is a useful method for evaluating treatment regimens for ulcerative colitis and that nicotine gum may be effective therapy for individual patients with ulceratives colitis who demonstrate an objective response with few adverse effects. Expand
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Cyclosporine enemas administered in a dosage of 350 mg/day for 4 weeks are not efficacious in mildly to moderately active left-sided ulcerative colitis. Expand
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It is concluded that oral 5-ASA administered in a dosage of 4.8 g per day is effective therapy, at least in the short term, for mildly to moderately active ulcerative colitis. Expand
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TLDR
It is reported that cigarette smokers were less likely to have ulcerative colitis than nonsmokers and that signs and symptoms of the disease disappered when the woman started smoking and reappeared when she stopped. Expand
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Jones and his colleagues at King's College Hospital have shown that hosiery exerting a pressure of 20mm Hg at the ankle was significantly less effective than that exerting pressures of 30-50 mm Hg, both in patients with superficial varicose veins and in those with postphlebitic limbs. Expand
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