Transdermal Extraction of Analytes Using Low-Frequency Ultrasound

  title={Transdermal Extraction of Analytes Using Low-Frequency Ultrasound},
  author={Samir Mitragotri and Matthew A. Coleman and Joseph Kost and Robert Langer},
  journal={Pharmaceutical Research},
Purpose. Transdermal extraction of clinically relevant analytes offersa potentially non-invasive method of diagnostics. However,development of such a method is limited by the low skin permeability. In thispaper, we report a potential method for non-invasive diagnostics basedon ultrasonic skin permeabilization and subsequent extraction ofinterstitial fluid (ISF) across the skin.Methods. In vivo experiments were performed using Sprague Dawleyrats to assess ultrasound-induced skin permeabilization… CONTINUE READING

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