Transdermal Estradiol/Norethisterone

  title={Transdermal Estradiol/Norethisterone},
  author={L. Wiseman and D. McTavish},
  journal={Drugs & Aging},
  • L. Wiseman, D. McTavish
  • Published 1994
  • Medicine
  • Drugs & Aging
  • SummarySynopsisThe combined transdermal estradiol/norethisterone therapeutic system is designed to deliver both estradiol and norethisterone into the systemic circulation at a constant rate for up to 4 days when affixed to the skin. Transdermal administration avoids hepatic first- pass metabolism, allowing therapeutic concentrations of the progestogen and estrogen to be maintained in postmenopausal women following low dose administration. Transdermal norethisterone does not appear to alter the… CONTINUE READING
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