Transdermal Delivery of Etoposide Phosphate I: In Vitro and In Vivo Evaluation.

  title={Transdermal Delivery of Etoposide Phosphate I: In Vitro and In Vivo Evaluation.},
  author={Hiren H Patel and Abhay Joshi and Amit Joshi and Grazia Stagni},
  journal={Journal of pharmaceutical sciences},
  volume={105 7},
Cancer chemotherapy frequently requires long periods of multiple intravenous infusions that often results in patients opting out of treatment. The main purpose of this study was to investigate the feasibility of delivering one of these anticancer agents: etoposide phosphate (ETP) transdermally using iontophoresis and a combination of iontophoresis/microporation. The iontophoresis conditions for ETP were first optimized in vitro then tested in vivo in a rabbit model. Both ETP and its active form… CONTINUE READING
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