Transdermal Assessment of Cortisol Awakening Response by Microneedle Perforation Technique

  title={Transdermal Assessment of Cortisol Awakening Response by Microneedle Perforation Technique},
  author={Shusaku Nomura and Masako Ohira and Kenta Suzuki and Ayako Nozaki and Yasuo Kikkawa and Toshiyuki Sato},
  journal={Journal of Life Support Engineering},
Transdermal assessment of cortisol awakening response (CAR) by microneedle perforation technique was regarded. CAR is a prominent cortisol variation after awakening. Since it has been reported to associate with chronic or daily stress, CAR is assumed as a possible stress indication. However CAR determination by saliva has methodological disadvantages such as lower compliance of multiple specimen collection, bold estimation of total cortisol by discrete sampling time points, etc. We then… 


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