Transcutaneous vaccination with virus-like particles.

  title={Transcutaneous vaccination with virus-like particles.},
  author={Sarah L. Young and Michelle M Wilson and Sarah K Wilson and Kenneth W. Beagley and Vernon V. Ward and Margaret A. Baird},
  volume={24 26},
Virus-like particles (VLP) are inert, empty capsids of viruses, which contain no DNA/RNA from the virus itself. However they retain the structure of a virus and they can be engineered to have antigens attached. We have constructed VLP, derived from Rabbit hemorrhagic disease virus, and shown they are highly immunogenic. We tested the capacity of these engineered VLP to induce immune responses when they are administered to mice via the transcutaneous route. This route of vaccination is important… CONTINUE READING


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