Transcutaneous immunization with an outer membrane protein of Porphyromonas gingivalis without adjuvant elicits marked antibody responses.

@article{Koizumi2008TranscutaneousIW,
  title={Transcutaneous immunization with an outer membrane protein of Porphyromonas gingivalis without adjuvant elicits marked antibody responses.},
  author={Yukiko Koizumi and Tomoko Kurita-Ochiai and Masafumi Yamamoto},
  journal={Oral microbiology and immunology},
  year={2008},
  volume={23 2},
  pages={
          131-8
        }
}
BACKGROUND/AIMS We have previously reported that specific immunoglobulin G (IgG) antibodies induced by transcutaneous immunization (TCI) with a 40-kDa outer membrane protein (40k-OMP) of Porphyromonas gingivalis, with cholera toxin (CT) as adjuvant, inhibited coaggregation by P. gingivalis. In this study, we further pursue the potential of the 40k-OMP as a transcutaneous vaccine. METHODS/RESULTS TCI of rats administered 40k-OMP elicited significant 40k-OMP-specific serum IgG and IgA, as well… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-3 of 3 citations

References

Publications referenced by this paper.
Showing 1-10 of 47 references

Specific anti bodies induced by nasally administered 40-kDa outer membrane protein of Porphyromonas gingivalis

  • J Namikoshi, S Otake, S Maeda, M Hayakawa, Y Abiko, M. Yamamoto
  • Vaccine
  • 2003
Highly Influential
5 Excerpts

Periodontal disease and systemic conditions: a bidirectional relationship

  • J Kims, S. Amar
  • Odontology
  • 2006
1 Excerpt