Transcutaneous delivery of levodopa: enhancement by fatty acid synthesis inhibition.

@article{Babita2005TranscutaneousDO,
  title={Transcutaneous delivery of levodopa: enhancement by fatty acid synthesis inhibition.},
  author={Kumar Babita and Ashok Kumar Tiwary},
  journal={Molecular pharmaceutics},
  year={2005},
  volume={2 1},
  pages={
          57-63
        }
}
The present investigation aimed at evaluating the role of fatty acid synthesis inhibition in enhancing transcutaneous delivery of levodopa (LD). Rat epidermis was treated with ethanol and various doses of cerulenin (an inhibitor of fatty acid synthase enzyme system) for reducing the normal level of fatty acids. Calcium chloride (0.1 mM) and/or verapamil (1 microM) were coapplied to cerulenin treated skin in order to modulate duration of epidermal perturbation. These treated skin portions were… 

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