Transcutaneous DNA immunization following waxing-based hair depilation.

@article{Sloat2012TranscutaneousDI,
  title={Transcutaneous DNA immunization following waxing-based hair depilation.},
  author={Brian R. Sloat and Kaoru Kiguchi and Gang Xiao and John DiGiovanni and Wendy J. Maury and Zhengrong Cui},
  journal={Journal of controlled release : official journal of the Controlled Release Society},
  year={2012},
  volume={157 1},
  pages={
          94-102
        }
}
Transcutaneous DNA immunization is an attractive immunization approach. Previously, we reported that transcutaneous immunization by applying plasmid DNA onto a skin area wherein the hair follicles had been induced into growth stage by 'cold' waxing-based hair plucking significantly enhanced the resultant immune responses. In the present study, using a plasmid that encodes the Bacillus anthracis protective antigen (PA63) gene fragment, it was shown that the anti-PA63 antibody responses induced… CONTINUE READING
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