Transcripts from an aberrantly re-arranged human T-cell receptor beta-chain gene.


A number of cDNA clones homologous to the human T-cell receptor beta-chain gene have been isolated from a library constructed from the human leukaemic cell line Jurkat. The nucleotide sequences of two of these clones demonstrate that Jurkat synthesizes an RNA, probably derived from an aberrantly rearranged C beta 1 gene, which cannot encode a functional beta-chain. This transcript contains a novel joining region and similar transcripts appear to be relatively abundant in several T-cell lines.


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@article{Collins1985TranscriptsFA, title={Transcripts from an aberrantly re-arranged human T-cell receptor beta-chain gene.}, author={M K Collins and A M Kissonerghis and Mark Dunne and C J Watson and Peter W. J. Rigby and M. J. Owen}, journal={The EMBO journal}, year={1985}, volume={4 5}, pages={1211-5} }