Transcripts from a mosquito dihydrofolate reductase gene: evidence for heterogeneity at the 5' end.

@article{Park1993TranscriptsFA,
  title={Transcripts from a mosquito dihydrofolate reductase gene: evidence for heterogeneity at the 5' end.},
  author={Youn Jung Park and Ann M Fallon},
  journal={Insect biochemistry and molecular biology},
  year={1993},
  volume={23 2},
  pages={255-62}
}
Heterogeneity among transcripts from the mosquito (Aedes albopictus) dihydrofolate reductase (DHFR) gene in wild-type C7-12 cells and in methotrexate-resistant Mtx-5011-128 cells has been analyzed by Northern blotting, RNAase mapping, and primer extension. In both sensitive and resistant cells, a major transcription initiation site mapped c. 11 nucleotides downstream of the TATAA box, near position -66 relative to the AUG codon. Two other major transcription initiation sites mapped approx… CONTINUE READING