Transcripts for the acetylcholine receptor and acetylcholine esterase show distribution differences in cultured chick muscle cells

@article{Tsim1992TranscriptsFT,
  title={Transcripts for the acetylcholine receptor and acetylcholine esterase show distribution differences in cultured chick muscle cells},
  author={Karl Wati-Keung Tsim and Ian Greenberg and Mendell Rimer and William R. Randall and Miriam M. Salpeter},
  journal={The Journal of Cell Biology},
  year={1992},
  volume={118},
  pages={1201 - 1212}
}
In situ hybridization of chick cultured muscle cells using exonic DNA probes for both AChR alpha-sub-unit and the catalytic subunit of AChE, revealed major differences in the distribution of label both over nuclei and in their surrounding cytoplasm, although some overlap in these distributions exists. For the AChR alpha-subunit there is a highly skewed distribution of labeled nuclei, with 35% of the nuclei being relatively inactive (less than 0.25 times the mean label) and approximately 10… CONTINUE READING

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