Transcriptomic profiling of chemical exposure reveals roles of Yap1 in protecting yeast cells from oxidative and other types of stresses.

@article{Zhang2016TranscriptomicPO,
  title={Transcriptomic profiling of chemical exposure reveals roles of Yap1 in protecting yeast cells from oxidative and other types of stresses.},
  author={Chao Zhang and Zhouquan Li and Xiaohua Zhang and Li Yuan and Heping Dai and Wei Xiao},
  journal={Yeast},
  year={2016},
  volume={33 1},
  pages={5-19}
}
Transcriptomic profiles are generated by comparing wild-type and the yeast yap1 mutant to various chemicals in an attempt to establish a correlation between this gene mutation and chemical exposure. Test chemicals include ClonNAT as a non-genotoxic agent, methyl methanesulphonate (MMS) as an alkylating agent, tert-butyl hydroperoxide (t-BHP) as an oxidative agent and the mixture of t-BHP and MMS to reflect complex natural exposure. Differentially expressed genes (DEGs) were identified and… CONTINUE READING
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