Transcriptomic network support distinct roles of classical and non-classical monocytes in human.

@article{Anbazhagan2014TranscriptomicNS,
  title={Transcriptomic network support distinct roles of classical and non-classical monocytes in human.},
  author={Kolandaswamy Anbazhagan and Isabelle Duroux-Richard and Christian Jorgensen and Florence Apparailly},
  journal={International reviews of immunology},
  year={2014},
  volume={33 6},
  pages={470-89}
}
Classical and non-classical monocytes are two well-defined subsets of monocytes displaying distinct roles. They differentially express numerous genes relevant to their primary role. Using five independent transcriptomic microarray datasets, we ruled out several inconsistent genes and identified common genes consistently overexpressed either in classical or non-classical monocytes. One hundred and eight genes were significantly increased in classical monocytes and are involved in bacterial… CONTINUE READING

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