Transcriptomic gene signatures associated with persistent airflow limitation in patients with severe asthma.

@article{Hekking2017TranscriptomicGS,
  title={Transcriptomic gene signatures associated with persistent airflow limitation in patients with severe asthma.},
  author={P. W. Hekking and Matthew J. Loza and Stelios Pavlidis and Bertrand de Meulder and Diane Lefaudeux and Fr{\'e}d{\'e}ric Baribaud and Charles Auffray and Ariane H. Wagener and Paul Brinkman and Ren{\'e} Lutter and Aruna T Bansal and Ana Maria Ribeiro de Sousa and Stewart A Bates and Ioannis Pandis and Louise J Fleming and Dominick E Shaw and Stephen J Fowler and Yike Guo and Andrea Meiser and Kai Sun and Julie Corfield and Peter Howarth and Elisabeth H.D. Bel and Ian M. Adcock and Kian Fan Chung and Ratko Djukanovi{\'c} and Peter J. Sterk},
  journal={The European respiratory journal},
  year={2017},
  volume={50 3}
}
A proportion of severe asthma patients suffers from persistent airflow limitation (PAL), often associated with more symptoms and exacerbations. Little is known about the underlying mechanisms. Here, our aim was to discover unexplored potential mechanisms using Gene Set Variation Analysis (GSVA), a sensitive technique that can detect underlying pathways in heterogeneous samples.Severe asthma patients from the U-BIOPRED cohort with PAL (post-bronchodilator forced expiratory volume in 1 s/forced… CONTINUE READING