Transcriptomic and CRISPR/Cas9 technologies reveal FOXA2 as a tumor suppressor gene in pancreatic cancer.

@article{Vorvis2016TranscriptomicAC,
  title={Transcriptomic and CRISPR/Cas9 technologies reveal FOXA2 as a tumor suppressor gene in pancreatic cancer.},
  author={Christina Vorvis and Maria Hatziapostolou and Swapna Mahurkar-Joshi and Marina Koutsioumpa and J. Williams and Timothy R. Donahue and George A. Poultsides and Guido Eibl and Dimitrios C. Iliopoulos},
  journal={American journal of physiology. Gastrointestinal and liver physiology},
  year={2016},
  volume={310 11},
  pages={G1124-37}
}
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer with low survival rates and limited therapeutic options. Thus elucidation of signaling pathways involved in PDAC pathogenesis is essential for identifying novel potential therapeutic gene targets. Here, we used a systems approach to elucidate those pathways by integrating gene and microRNA… CONTINUE READING