Transcriptomic analyses of chemokines reveal that down-regulation of XCR1 is associated with advanced hepatocellular carcinoma.

@article{Yanru2018TranscriptomicAO,
  title={Transcriptomic analyses of chemokines reveal that down-regulation of XCR1 is associated with advanced hepatocellular carcinoma.},
  author={Wang Yanru and Bai Zhenyu and Niu Zhengchuan and Qi Qi and Liang Chunmin and Yao Weiqiang},
  journal={Biochemical and biophysical research communications},
  year={2018},
  volume={496 4},
  pages={1314-1321}
}
Chemokines are essential coordinators of cellular migration and cell-cell interactions, therefore considerable attention has been paid to the application of chemokines to cancer immunotherapy. In this study, we screened for the expression levels of 58 human chemokines/chemokine receptors in hepatocellular carcinoma (HCC) by using samples from the TCGA LIHC cohort and found 16 consistently down-regulated and 11 up-regulated chemokine genes in HCC compared with normal samples. Furthermore, the… CONTINUE READING
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