Transcriptomic Identification of Iron-Regulated and Iron-Independent Gene Copies within the Heavily Duplicated Trichomonas vaginalis Genome

@inproceedings{Horvthov2012TranscriptomicIO,
  title={Transcriptomic Identification of Iron-Regulated and Iron-Independent Gene Copies within the Heavily Duplicated Trichomonas vaginalis Genome},
  author={Lenka Horv{\'a}thov{\'a} and Lucie {\vS}afař{\'i}kov{\'a} and Marek Basler and Ivan Hrd{\'y} and Neritza B. Campo and Jyh-Wei Shin and Kuo-Yang Huang and Po-Jung Huang and Rose Lin and Petrus Tang and Jan Tachez{\'y}},
  booktitle={Genome biology and evolution},
  year={2012}
}
Gene duplication is an important evolutionary mechanism and no eukaryote has more duplicated gene families than the parasitic protist Trichomonas vaginalis. Iron is an essential nutrient for Trichomonas and plays a pivotal role in the establishment of infection, proliferation, and virulence. To gain insight into the role of iron in T. vaginalis gene expression and genome evolution, we screened iron-regulated genes using an oligonucleotide microarray for T. vaginalis and by comparative EST… CONTINUE READING
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