Transcriptomic Analysis of Autistic Brain Reveals Convergent Molecular Pathology

  title={Transcriptomic Analysis of Autistic Brain Reveals Convergent Molecular Pathology},
  author={Irina Voineagu and Xinchen Wang and Patrick Johnston and Jennifer K. Lowe and Yuan Tian and Steve Horvath and Jonathan Mill and Rita M. Cantor and Benjamin J. Blencowe and Daniel H. Geschwind},
Autism spectrum disorder (ASD) is a common, highly heritable neurodevelopmental condition characterized by marked genetic heterogeneity. Thus, a fundamental question is whether autism represents an aetiologically heterogeneous disorder in which the myriad genetic or environmental risk factors perturb common underlying molecular pathways in the brain. Here, we demonstrate consistent differences in transcriptome organization between autistic and normal brain by gene co-expression network analysis… CONTINUE READING
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