Transcriptome-wide miR-155 binding map reveals widespread noncanonical microRNA targeting.

Abstract

MicroRNAs (miRNAs) are essential components of gene regulation, but identification of miRNA targets remains a major challenge. Most target prediction and discovery relies on perfect complementarity of the miRNA seed to the 3' untranslated region (UTR). However, it is unclear to what extent miRNAs target sites without seed matches. Here, we performed a… (More)
DOI: 10.1016/j.molcel.2012.10.002

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