Transcriptome-wide distribution and function of RNA hydroxymethylcytosine

  title={Transcriptome-wide distribution and function of RNA hydroxymethylcytosine},
  author={Benjamin Delatte and Fei Wang and Long Vo Ngoc and Evelyne Collignon and Elise Bonvin and Rachel Deplus and Emilie Calonne and Bouchra Hassabi and Pascale Putmans and Stephan Awe and Collin Wetzel and Judith Kreher and Romuald Soin and Catherine Creppe and Patrick A. Limbach and Cyril Gueydan and V{\'e}ronique Kruys and Alexander Brehm and Svetlana Minakhina and Matthieu Defrance and R. Steward and François Fuks},
Hydroxymethylcytosine, well described in DNA, occurs also in RNA. Here, we show that hydroxymethylcytosine preferentially marks polyadenylated RNAs and is deposited by Tet in Drosophila. We map the transcriptome-wide hydroxymethylation landscape, revealing hydroxymethylcytosine in the transcripts of many genes, notably in coding sequences, and identify consensus sites for hydroxymethylation. We found that RNA hydroxymethylation can favor mRNA translation. Tet and hydroxymethylated RNA are found… CONTINUE READING