Transcriptome-wide Identification and Validation of Interactions between the miRNA Machinery and HuR on mRNA Targets.

@article{Li2018TranscriptomewideIA,
  title={Transcriptome-wide Identification and Validation of Interactions between the miRNA Machinery and HuR on mRNA Targets.},
  author={Yahui Li and Jason A. Estep and Fedor V. Karginov},
  journal={Journal of molecular biology},
  year={2018},
  volume={430 3},
  pages={
          285-296
        }
}
The 3' untranslated region (UTR) of mRNAs is the primary regulatory region that mediates post-transcriptional control by microRNAs and RNA-binding proteins in the cytoplasm. Aside from individual sequence-specific binding and regulation, examples of interaction between these factors at particular 3' UTR sites have emerged. However, the whole picture of such higher-order regulatory modules across the transcriptome is lacking. Here, we investigate the interactions between HuR, a ubiquitous RNA… CONTINUE READING
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