Transcriptome profiling reveals links between ParS/ParR, MexEF-OprN, and quorum sensing in the regulation of adaptation and virulence in Pseudomonas aeruginosa

@inproceedings{Wang2013TranscriptomePR,
  title={Transcriptome profiling reveals links between ParS/ParR, MexEF-OprN, and quorum sensing in the regulation of adaptation and virulence in Pseudomonas aeruginosa},
  author={Dongping Wang and Candace Seeve and Leland Stanley Pierson and Elizabeth A. Pierson},
  booktitle={BMC Genomics},
  year={2013}
}
The ParS/ParR two component regulatory system plays critical roles for multidrug resistance in Pseudomonas aeruginosa. It was demonstrated that in the presence of antimicrobials, ParR enhances bacterial survival by distinct mechanisms including activation of the mexXY efflux genes, enhancement of lipopolysaccharide modification through the arn operon, and reduction of the expression of oprD porin. In this study, we report on transcriptomic analyses of P. aeruginosa PAO1 wild type and parS and… CONTINUE READING

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