Transcriptome of local innate and adaptive immunity during early phase of infectious bronchitis viral infection.

Abstract

To understand the mechanistic basis of local innate and adaptive immunity against infectious bronchitis virus (IBV) at the molecular level, we examined the gene transcription profile of tracheal epithelial layers 3 d after infection of chickens with an attenuated IBV-Massachusetts strain. Results suggested that the transcription levels of 365 genes were either upregulated or downregulated (2-fold and higher) after IBV infection. Among the upregulated 250 genes, 25 were directly immune-related genes. These upregulated immune response genes included TLR2, TLR3, interferon-induced antiviral genes (Mx), and genes responsible for cytotoxic T cell killing such as Fas antigen and granzyme-A. Overall, a diversity of innate immunity and helper T cell type 1 (Th1)-biased adaptive immunity are activated in the host's early defense against IBV invasion, and they are responsible for the rapid clearance of virus from the local infection.

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@article{Wang2006TranscriptomeOL, title={Transcriptome of local innate and adaptive immunity during early phase of infectious bronchitis viral infection.}, author={Xiuqing Wang and Artur Jord{\~a}o de Magalh{\~a}es Rosa and Henrique N Oliverira and Guilherme J. M. Rosa and Xueshui Guo and Mark Travnicek and Theodore Girshick}, journal={Viral immunology}, year={2006}, volume={19 4}, pages={768-74} }