Transcriptome maps of mRNP biogenesis factors define pre-mRNA recognition.

@article{Baejen2014TranscriptomeMO,
  title={Transcriptome maps of mRNP biogenesis factors define pre-mRNA recognition.},
  author={Carlo Baejen and Phillipp Torkler and Saskia Gressel and Katharina Essig and Johannes S{\"o}ding and Patrick Cramer},
  journal={Molecular cell},
  year={2014},
  volume={55 5},
  pages={745-57}
}
Biogenesis of eukaryotic messenger ribonucleoprotein complexes (mRNPs) involves the synthesis, splicing, and 3' processing of pre-mRNA, and the assembly of mature mRNPs for nuclear export. We mapped 23 mRNP biogenesis factors onto the yeast transcriptome, providing 10(4)-10(6) high-confidence RNA interaction sites per factor. The data reveal how mRNP biogenesis factors recognize pre-mRNA elements in vivo. They define conserved interactions between splicing factors and pre-mRNA introns… CONTINUE READING
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