Transcriptome and proteome analysis of early embryonic mouse brain development.

  title={Transcriptome and proteome analysis of early embryonic mouse brain development.},
  author={Daniela Hartl and Martin Irmler and Irmgard Roemer and Michael T. Mader and Lei Mao and Claus Zabel and Martin Hrabe de Angelis and J. V. L. Beckers and Joachim Klose},
  volume={8 6},
Mouse embryonic brain development involves sequential differentiation of multipotent progenitors into neurons and glia cells. Using microarrays and large 2-DE, we investigated the mouse brain transcriptome and proteome of embryonic days 9.5, 11.5, and 13.5. During this developmental period, neural progenitor cells shift from proliferation to neuronal differentiation. As expected, we detected numerous expression changes between all time points investigated, but interestingly, the rate of… CONTINUE READING


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