Transcriptome and Genome Conservation of Alternative Splicing Events in Humans and Mice

@article{Sugnet2004TranscriptomeAG,
  title={Transcriptome and Genome Conservation of Alternative Splicing Events in Humans and Mice},
  author={Charles W. Sugnet and W. James Kent and Manuel Ares and David Haussler},
  journal={Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing},
  year={2004},
  pages={66-77}
}
Combining mRNA and EST data in splicing graphs with whole genome alignments, we discover alternative splicing events that are conserved in both human and mouse transcriptomes. 1,964 of 19,156 (10%) loci examined contain one or more such alternative splicing events, with 2,698 total events. These events represent a lower bound on the amount of alternative splicing in the human genome. Also, as these alternative splicing events are conserved between the human and mouse transcriptomes they should… CONTINUE READING
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