Transcriptome analysis of human gastric cancer

@article{Oh2005TranscriptomeAO,
  title={Transcriptome analysis of human gastric cancer},
  author={Jung-Hwa Oh and Jin Ok Yang and Y. Hahn and Mi-Rang Kim and Sang-Soon Byun and Y. Jeon and Jeong-Min Kim and K. Song and Seung-Moo Noh and Sangsoo Kim and H. Yoo and Y. S. Kim and Nam‐Soon Kim},
  journal={Mammalian Genome},
  year={2005},
  volume={16},
  pages={942-954}
}
To elucidate the genetic events associated with gastric cancer, 124,704 cDNA clones were collected from 37 human gastric cDNA libraries, including 20 full-length enriched cDNA libraries of gastric cancer cell lines and tissues from Korean patients. An analysis of the collected ESTs revealed that 97,930 high-quality ESTs coalesced into 13,001 clusters, of which 11,135 clusters (85.6%) were annotated to known ESTs. The analysis of the full-length cDNAs also revealed that 4862 clusters (51.7… Expand
Bioinformatical identification of key pathways and genes in human hepatocellular carcinoma after CSN5 depletion.
TLDR
Protein-protein interaction (PPI) network, Kaplan-Meier, log-rank method, western blot, immunohistochemistry and encyclopedia of DNA elements (ENCODE) analysis showed that CSN5 depletion took effects through down-regulation of SMAD5-related pathways which include EXO1, CENPA and NCAPG, resulting in the inactivation of H3K4me3 and H2K36me3. Expand
Pancreatic adenocarcinoma up‐regulated factor (PAUF), a novel up‐regulated secretory protein in pancreatic ductal adenocarcinoma
TLDR
The results suggest that pancreatic adenocarcinoma up‐regulated factor is a novel secretory protein involved in pancreatic cancer progression and might be a potential target for the treatment of pancreaticcancer. Expand
Construction of a novel prognostic-predicting model correlated to ovarian cancer
TLDR
The identified eight-mRNA signature has significant clinical implication for outcome prediction and tailored therapy guidance for OC patients, and may provide new perspective on the pathogenesis and treatments of OC. Expand
Role of tesmin expression in non-small cell lung cancer
TLDR
A positive association among tesmin, MCM5 and MCM7 protein expression in NSCLC and their association with the clinicopathological data of patients is indicated, which could indicate a possible role of tesmine in the proliferation ofNSCLC cancer cells. Expand
Cilia gene expression patterns in cancer.
TLDR
It is suggested that genes involved in cilia biosynthesis and function are frequently dysregulated in cancer, and may be useful for identifying and classifying cancer types. Expand
Analyses of the Interleukin32 Transcript Variants in Breast Cancer Cell Lines
TLDR
PCR analyses showed that the longer transcript variants contributed more to differential gene expression observed in the MDA MB231 compared to MCF7 cell lines, and investigators should consider strategies that target analyses of a combination of the longer IL32 transcript variants. Expand
Role of downregulation of galectin-9 in the tumorigenesis of gastric cancer.
TLDR
In patients with gastric cancer, clinical staging, tumor pathological stage (pT stage), tumor cell differentiation, lymph node metastasis and survival rate were found to be associated with Gal-9 expression, but no significant association was found between Gal- 9 expression and distant metastasis (p>.05). Expand
Higher tesmin expression in cancer cells compared to control cells may suggest a role of tesmin in NSCLC carcinogenesis. A positive correlation between tesmin and Ki‐67 could indicate a possible role of tesmin in the proliferation of NSCLC
Lung cancer is the most commonly diagnosed cancer and the most frequent cause of death worldwide. Tesmin (testis-specific metallothionein-like protein; MTL-5) is a 60-kDa protein which hasExpand
Molecular Targets in Gastric Cancer and Apoptosis
TLDR
This review provides an update (current up to April 6, 2008) on pathogenesis focusing on the specific abnormalities in gastric cancer genomes, conventional therapy approaches, genetic and epigenetic mechanisms of expression regulation, apoptotic pathways in Gastric cancer and new emerging or potential therapeutic approaches focused around molecularly defined gastric cancers. Expand
Long non-coding RNA ARHGAP5-AS1 inhibits migration of breast cancer cell via stabilizing SMAD7 protein
TLDR
Functional investigation showed ARHGAP5-AS1 inhibits breast cancer cell migration via stabilization of SMAD7 protein and could serve as a novel biomarker and a potential target for breast cancer in the future. Expand
...
1
2
3
...

References

SHOWING 1-10 OF 59 REFERENCES
Gene cataloging and expression profiling in human gastric cancer cells by expressed sequence tags.
TLDR
It was found that genes related to cell adhesion, apoptosis, and cytoskeleton formation were particularly up-regulated in the gastric cancer cell lines established from malignant ascites compared to those from primary tumors. Expand
Analysis of gene expression profiles of gastric normal and cancer tissues by SAGE.
TLDR
The genes identified in this study will provide useful target genes for diagnosis and molecular treatment of gastric cancer, as well as a few novel candidates. Expand
Identification of gastric cancer-related genes using a cDNA microarray containing novel expressed sequence tags expressed in gastric cancer cells.
TLDR
Novel genes that are related to human gastric cancer were identified using a novel 2K cDNA microarray developed in the laboratory and should provide a valuable resource for understanding the molecular mechanism associated with tumorigenesis of gastric carcinogenesis and for the discovery of potential diagnostic markers of Gastric cancer. Expand
Profiling, comparison and validation of gene expression in gastric carcinoma and normal stomach
TLDR
The gastric carcinoma profiles resembled other tumours', supporting the existence of common cancer-associated targets and providing a catalogue from which to develop markers for better diagnosis and therapy of gastrics carcinoma. Expand
Expression profiling and subtype-specific expression of stomach cancer.
TLDR
The data showed that stomach cancers could be clustered effectively using stomach-specific microarrays and pairwise analysis of tumor/nontumor mucosa couples and suggested that the application of specific goal-oriented experimental designing would be advantageous for efficient analysis of expression profiles of such a complex disease as gastric cancer. Expand
Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence.
TLDR
Almost 40% of identified human genes appear to be associated with basic energy metabolism, cell structure, homeostasis and cell division, 22% with RNA and protein synthesis and processing, and 12% with cell signalling and communication. Expand
Advances in Brief Frequent Somatic Mutations of the b-Catenin Gene in Intestinal-Type Gastric Cancer 1
The increased level of cytoplasmicb-catenin through the mutations to either b-cateninor adenomatous polyposis coli (APC) has been proposed as an important oncogenic step in various tumors. GastricExpand
Generation and analysis of 280,000 human expressed sequence tags.
TLDR
Comparisons of a subset of the data with nonredundant human mRNA and protein data bases show that the ESTs represent many known sequences and contain many that are novel, which supports the contention that although normalization reduces significantly the relative abundance of redundant cDNA clones, it does not result in the complete removal of members of gene families. Expand
Identification of Genes with Differential Expression in Acquired Drug-Resistant Gastric Cancer Cells Using High-Density Oligonucleotide Microarrays
TLDR
Midkine (MDK), a heparin-binding growth factor, was overexpressed in all drug-resistant cell lines, strongly suggesting that MDK might contribute to multidrug resistance in gastric cancer cells. Expand
Expression profile of differentially-regulated genes during progression of androgen-independent growth in human prostate cancer cells.
TLDR
These differentially-regulated genes are correlated with progression of human prostate cancer and may be of therapeutic relevance as well as an aid in understanding the molecular genetic events involved in the development of this disease's hormone-refractory behavior. Expand
...
1
2
3
4
5
...