Transcriptome analysis of alternative splicing events regulated by SRSF10 reveals position-dependent splicing modulation

@inproceedings{Zhou2014TranscriptomeAO,
  title={Transcriptome analysis of alternative splicing events regulated by SRSF10 reveals position-dependent splicing modulation},
  author={Xuexia Zhou and Wenwu Wu and Huang Li and Yuanming Cheng and Ning Wei and Jie Zong and Xiaoyan Feng and Zhiqin Xie and Dai Bo Chen and James L Manley and Hui Wang and Ying Feng},
  booktitle={Nucleic acids research},
  year={2014}
}
Splicing factor SRSF10 is known to function as a sequence-specific splicing activator. Here, we used RNA-seq coupled with bioinformatics analysis to identify the extensive splicing network regulated by SRSF10 in chicken cells. We found that SRSF10 promoted both exon inclusion and exclusion. Motif analysis revealed that SRSF10 binding to cassette exons was associated with exon inclusion, whereas the binding of SRSF10 within downstream constitutive exons was associated with exon exclusion. This… CONTINUE READING