Transcriptome analysis of HER2 reveals a molecular connection to fatty acid synthesis.

  title={Transcriptome analysis of HER2 reveals a molecular connection to fatty acid synthesis.},
  author={Chandan Kumar-Sinha and Kathleen M. Woods Ignatoski and Marc E. Lippman and Stephen P Ethier and Arul M. Chinnaiyan},
  journal={Cancer research},
  volume={63 1},
HER2 (erbB2/neu) is a member of the erbB family of receptor tyrosine kinases and is involved in regulating the growth of several types of human carcinomas. HER2 represents a successful therapeutic target of the biotechnology era as exemplified by the drug Herceptin (trastuzumab), which has clinical activity in a subset of breast cancer patients. Using DNA microarrays, we identified a cohort of genes that are differentially regulated by HER2 in breast epithelial cells. One of the HER2-regulated… CONTINUE READING


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