Transcriptome analysis identifies TNF superfamily receptors as potential therapeutic targets in alcoholic hepatitis.

@article{Aff2013TranscriptomeAI,
  title={Transcriptome analysis identifies TNF superfamily receptors as potential therapeutic targets in alcoholic hepatitis.},
  author={Silvia Aff{\`o} and Marlene Dom{\'i}nguez and Juan Jos{\'e} Lozano and Pau Sancho-Bru and Daniel Rodrigo-Torres and Oriol Morales-Ibanez and Montserrat Origel Moreno and Cristina Garc{\'i}a Mill{\'a}n and Aurora Loaeza-del-Castillo and Jos{\'e} S. Altamirano and Juan C Garc{\'i}a-Pag{\'a}n and Vicente Arroyo and Pere Gin{\`e}s and Juan Caballer{\'i}a and Robert F Schwabe and Ram{\'o}n Bataller},
  journal={Gut},
  year={2013},
  volume={62 3},
  pages={
          452-60
        }
}
OBJECTIVE Alcoholic hepatitis (AH) is a severe clinical condition that needs novel therapies. The identification of targets for therapy is hampered by the lack of animal models of advanced AH. The authors performed a translational study through a transcriptome analysis in patients with AH to identify new molecular targets. DESIGN Hepatic gene expression profiling was assessed by DNA microarray in patients with AH (n=15) and normal livers (n=7). Functional analysis was assessed by gene set… CONTINUE READING

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