Transcriptome analysis highlights the conserved difference between embryonic and postnatal-derived alveolar macrophages.

@article{Gibbings2015TranscriptomeAH,
  title={Transcriptome analysis highlights the conserved difference between embryonic and postnatal-derived alveolar macrophages.},
  author={Sophie L. Gibbings and Rajni Goyal and A Nicole Desch and Sonia M. Leach and Miglena Prabagar and Shaikh M. Atif and Donna L. Bratton and William Janssen and Claudia V. Jakubzick},
  journal={Blood},
  year={2015},
  volume={126 11},
  pages={1357-66}
}
Alveolar macrophages (AMs) reside on the luminal surfaces of the airways and alveoli where they maintain host defense and promote alveolar homeostasis by ingesting inhaled particulates and regulating inflammatory responses. Recent studies have demonstrated that AMs populate the lungs during embryogenesis and self-renew throughout life with minimal replacement by circulating monocytes, except under extreme conditions of depletion or radiation injury. Here we demonstrate that on a global scale… CONTINUE READING

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