Transcriptome analysis for Notch3 target genes identifies Grip2 as a novel regulator of myogenic response in the cerebrovasculature.

@article{Fouillade2013TranscriptomeAF,
  title={Transcriptome analysis for Notch3 target genes identifies Grip2 as a novel regulator of myogenic response in the cerebrovasculature.},
  author={Charles Fouillade and C{\'e}line Baron-Menguy and Val{\'e}rie Domenga-Denier and Christelle Thibault and Kogo Takamiya and Richard L. Huganir and Anne Joutel},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={2013},
  volume={33 1},
  pages={76-86}
}
OBJECTIVE Notch3 is critically important for the structure and myogenic response of distal arteries, particularly of cerebral arteries. However, signaling pathways acting downstream of Notch3 remain largely unknown. METHODS AND RESULTS Transcriptome analysis using tail arteries of Notch3-null mice identified a core set of 17 novel Notch3-regulated genes confirmed in tail or brain arteries. Postnatal deletion of RBP-Jκ in smooth muscle cells recapitulated the structural, functional, and… CONTINUE READING
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