Transcriptome analysis and gene expression profiles of early apoptosis-related genes in Streptococcus pyogenes-infected epithelial cells.

@article{Nakagawa2004TranscriptomeAA,
  title={Transcriptome analysis and gene expression profiles of early apoptosis-related genes in Streptococcus pyogenes-infected epithelial cells.},
  author={Ichiro Nakagawa and Masanobu Nakata and Shigetada Kawabata and Shigeyuki Hamada},
  journal={Cellular microbiology},
  year={2004},
  volume={6 10},
  pages={
          939-52
        }
}
Epithelial cells are the initial sites of host invasion by group A Streptococcus pyogenes (GAS), and GAS infection of epithelial cells has been suggested to induce apoptosis. We previously reported that the induction of apoptosis is strongly associated with the protein F1-mediated invasion. We present here the gene expression profiles of the human epithelial HEp-2 cells during GAS-induced apoptosis, using serial gene analysis of expression (SAGE) analysis and macroarray analysis of apoptosis… CONTINUE READING

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