Transcriptome activity of isochores during preimplantation process in human and mouse.

  title={Transcriptome activity of isochores during preimplantation process in human and mouse.},
  author={Carl Barton and Costas S. Iliopoulos and Solon P. Pissis and Stilianos Arhondakis},
  journal={FEBS letters},
  volume={590 14},
This work investigates the role of isochores during preimplantation process. Using RNA-seq data from human and mouse preimplantation stages, we created the spatio-temporal transcriptional profiles of the isochores during preimplantation. We found that from early to late stages, GC-rich isochores increase their expression while GC-poor ones decrease it. Network analysis revealed that modules with few coexpressed isochores are GC-poorer than medium-large ones, characterized by an opposite… CONTINUE READING
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