Transcriptome-Wide Assessment of Human Brain and Lymphocyte Senescence

@article{Hong2008TranscriptomeWideAO,
  title={Transcriptome-Wide Assessment of Human Brain and Lymphocyte Senescence},
  author={Mun-Gwan Hong and Amanda Jennings Myers and Patrik K. E. Magnusson and Jonathan A. Prince},
  journal={PLoS ONE},
  year={2008},
  volume={3},
  pages={165 - 175}
}
BACKGROUND Identifying biological pathways that vary across the age spectrum can provide insight into fundamental mechanisms that impact disease and frailty in the elderly. Few methodological approaches offer the means to explore this question on as broad a scale as gene expression profiling. Here, we have evaluated mRNA expression profiles as a function of age in two populations; one consisting of 191 individuals with ages-at-death ranging from 65-100 years and with post-mortem brain mRNA… CONTINUE READING

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