Transcriptome Sequencing of Gene Expression in the Brain of the HIV-1 Transgenic Rat

  title={Transcriptome Sequencing of Gene Expression in the Brain of the HIV-1 Transgenic Rat},
  author={Ming D. Li and Junran Cao and Shaolin Wang and Ju Hong Wang and Sraboni Sarkar and Michael Vigorito and Jennie Z Ma and Sulie L. Chang},
  booktitle={PloS one},
The noninfectious HIV-1 transgenic (HIV-1Tg) rat was developed as a model of AIDs-related pathology and immune dysfunction by manipulation of a noninfectious HIV-1(gag-pol) virus with a deleted 3-kb SphI-MscI fragment containing the 3' -region of gag and the 5' region of pol into F344 rats. Our previous studies revealed significant behavioral differences between HIV-1Tg and F344 control rats in their performance in the Morris water maze and responses to psychostimulants. However, the molecular… CONTINUE READING
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