Transcriptome Profiling of Pediatric Core Binding Factor AML

  title={Transcriptome Profiling of Pediatric Core Binding Factor AML},
  author={Chih-Hao Hsu and Cu Nguyen and Chunhua Yan and Rhonda E Ries and Qing-Rong Chen and Ying Hu and Fabiana Ostronoff and Derek L. Stirewalt and George Komatsoulis and Shawn Levy and Daoud Meerzaman and Soheil Meshinchi and Ken Mills},
  booktitle={PloS one},
The t(8;21) and Inv(16) translocations disrupt the normal function of core binding factors alpha (CBFA) and beta (CBFB), respectively. These translocations represent two of the most common genomic abnormalities in acute myeloid leukemia (AML) patients, occurring in approximately 25% pediatric and 15% of adult with this malignancy. Both translocations are associated with favorable clinical outcomes after intensive chemotherapy, and given the perceived mechanistic similarities, patients with… CONTINUE READING
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