Transcriptome Profile of Rat Adrenal Evoked by Gonadectomy and Testosterone or Estradiol Replacement

@inproceedings{Jopek2017TranscriptomePO,
  title={Transcriptome Profile of Rat Adrenal Evoked by Gonadectomy and Testosterone or Estradiol Replacement},
  author={Karol Jopek and Piotr Celichowski and Marta Szyszka and Marianna Tyczewska and Paulina Milecka and Ludwik Kazimierz Malendowicz and Marcin Rucinski},
  booktitle={Front. Endocrinol.},
  year={2017}
}
Sex differences in adrenal cortex structure and function are well known in different species. In the rat, they are manifested as larger adrenal cortex and higher corticosterone secretion by females compared with males. These sex differences depend, among others, on functioning of the hypothalamic-pituitary-adrenal axis (HPA). In this aspect, it is widely accepted that testosterone exerts an inhibitory and estradiol stimulatory effect on the said axis. The molecular bases of these sex-related… CONTINUE READING
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