Transcriptionally targeted retroviral vector for combined suicide and immunomodulating gene therapy of thyroid cancer.


Gene therapy may be an effective approach to thyroid carcinoma refractory to conventional treatment. A transcriptionally targeted retroviral vector for gene therapy of thyroid carcinomas was generated replacing the viral enhancer with the enhancer sequence of the human thyroglobulin (TG) gene, yielding a chimeric long-terminal repeat. The TG enhancer was… (More)


  • Presentations referencing similar topics